TMG - 99% purity powder - 50g

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TMG is a compound that consists of glycine with three attached methyl groups.
It’s produced by your body and is found naturally in beetroot and other foods. It’s also available as a supplement, sometimes used to enhance athletic performance and improve heart and liver health
Studies suggest that TMG could decrease homocysteine levels, boost athletic performance, improve insulin resistance, and enhance the effectiveness of certain antidepressants.

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How does TMG function?

TMG, also known as trimethylglycine, is a vital nutrient that plays a role in preventing chronic diseases and maintaining the health of the liver, heart, and kidneys.

Researchers in the field of anti-aging recommend combining NMN with Resveratrol and TMG for optimal results.

When taken alongside NMN supplements, TMG acts as a methyl donor, supporting various bodily processes that require methylation. This includes the activation of sirtuins, which promote longevity and repair.

Potential benefits

TMG supplements have been associated with several potential health benefits.

May lower homocysteine levels for improved heart health

Research suggests that TMG may help decrease blood levels of homocysteine, an amino acid that, when elevated, can increase the risk of heart disease (3Trusted Source).

A review of five studies conducted in 2013 found that taking at least 4 grams of TMG per day for 6 weeks resulted in lower homocysteine levels in healthy adults (4Trusted Source).

Another review supported these findings, indicating that 4 grams of TMG per day could lower homocysteine levels without negatively affecting other aspects of heart health, such as blood pressure or triglyceride levels (5Trusted Source).

However, it's worth noting that some studies, both older and more recent, have suggested that TMG supplements may increase total and LDL (bad) cholesterol levels, which are risk factors for heart disease (6Trusted Source, 7Trusted Source).

Further research is needed to fully understand the impact of TMG supplements on heart health.

Could enhance athletic performance

Many athletes use TMG supplements to potentially improve their exercise performance.

One review reported that TMG supplements could enhance body composition and improve performance in both endurance and resistance exercises (8Trusted Source).

Although the exact mechanisms are not yet fully understood, researchers speculate that TMG may (8Trusted Source):

  • Reduce fatigue
  • Boost protein production
  • Increase the synthesis of creatine, a compound that provides energy to muscle cells

Another review of seven studies yielded mixed results. However, it did note that TMG supplements significantly increased muscle strength and power in two of the studies (9Trusted Source).

Nevertheless, several other studies have shown no significant impact of TMG on exercise performance or strength. Therefore, more research is necessary before TMG can be confidently recommended as a supplement for enhancing athleticism (10Trusted Source, 11Trusted Source, 12Trusted Source).

May help prevent insulin resistance

Several studies have indicated that TMG supplements could potentially improve insulin resistance, a condition that impairs the body's ability to use insulin to regulate blood sugar levels (13Trusted Source).

For instance, one study involving nearly 2,400 individuals found that higher intake of choline and betaine, both of which are found in TMG, was associated with decreased insulin resistance.

Additionally, an animal study showed that administering TMG supplements to mice on a high-fat diet improved fat metabolism and reduced insulin resistance.

Furthermore, a mouse study conducted in 2010 found that TMG supplements could reverse insulin resistance in the liver, where insulin is ineffective at suppressing sugar production.

However, more research is needed to fully understand how TMG may affect insulin resistance in humans.

Could potentially improve symptoms of depression

Some research suggests that TMG supplements may improve the effectiveness of certain types of antidepressant medications.

In particular, TMG has been shown to enhance the effects of S-adenosyl-methionine (SAMe), a medication used to treat mild to moderate depression (17Trusted Source, 18).

Interestingly, a small study involving 64 individuals with depression found that those who took both SAMe and TMG for 12 months experienced greater improvement in their symptoms compared to those who took SAMe alone (19Trusted Source).

Furthermore, TMG may also help alleviate symptoms of depression and anxiety, as these conditions have been linked to elevated homocysteine levels that TMG can potentially lower.

How to use TMG?

  • Ensure the purity of TMG is over 99%.
  • The recommended daily dose is up to 1 gram.
  • Do not exceed the stated recommended daily dose.
  • Store TMG in a cool and dark place, out of reach of children.
  • A free 0.5 ml measuring spoon is included. Please note that the weight the spoon holds may vary depending on the density of the supplement. The spoon holds 0.5g TMG and is dishwasher safe.

TMG is generally well-tolerated, but some individuals may experience mild digestive upset or headaches as side effects.

It is not recommended for pregnant or breastfeeding individuals due to a lack of data.

Remember, food supplements should not be used as a substitute for a varied diet.